This volumes examines the mechanisms that underlie the generation of sensory and motor activity in the functional and dysfunctional spinal cord: a cutting-edge model system for both basic and translational neuroscience. At the basic neuroscience level, the volume explores the functional organization of neuronal networks responsible for processing sensory inputs and generating motor outputs and the genes that control the assembly of these networks. At the translational neuroscience level, articles describe approaches to understand and therapeutically modify spinal network responses to pain and injury. Articles cover a wide range of topics from genetic, synaptic, and cellular mechanisms underlying network development and functions to plasticity and regeneration following spinal cord injury. NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas. ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit http://www.nyas.org/MemberCenter/Join.aspx for more information about becoming a member.