Throughout history, vaccines have controlled and eradicated many deadly diseases. Still, a small segment of the population railed against them, whether for religious or health reasons. The issue came to the forefront during the rollout of the COVID-19 vaccine, turning a public health matter into a battle over personal liberty. The diverse viewpoints in this resource debate the impact of vaccines on public and private health; the power of the media, politicians, and public figures to sway consumers; and the future of vaccines, particularly in a world that promises more pandemics to come.