On the run from a ruthless DNA-cloning scientist, Barry, a brown-and-white one-year-old Jack Russell terrier, becomes homeless on the streets of Virginia Beach, Virginia. Duncan Perkins, the nutty scientist with aid from six millionaires called the Commission, experimented on lots of canines with deadly results. Fed up with Duncan's failures, the Commission funded him a large iron box Duncan named the Duplicator. With very few animals left to work with, he chose Barry's mother as his next victim. During a trial run of the Duplicator, tragedy struck. Barry's mother didn't survive. Days later, after arguing with the Commission about the incident, he was granted ten assistants also funded by them. Duncan continued his sick, twisted experiments. He ordered his assistants to inject five shots each into Barry's siblings and Barry. The siblings died several days later, but Barry survived. During a cleaning at the lab, the janitor bumped against Barry's cage, causing the lock to loosen. He escaped through the door to freedom. Now on the streets, those shots started a transformation within him. Telepathy was his first gift. Duncan was furious about his escape. He knew his funding would be in jeopardy, but he had an upper hand against the Commission as well. Working with his employers was a sassy blonde named Miriam. She was a pure snake in high heels. When word was out about termination of his lab funding, he connected with Miriam to concoct a plan against his employers. He ordered his assistants to create four more Barrys. Still on the streets, Barry befriended a couple from North Carolina. They loved him even though he had supernatural gifts. When Duncan found out Barry was headed to North Carolina, he sent Felix, his most trusted man, to track him down. Felix failed, along with others. Now tormented with pure hate and greed, he decided with Miriam to put his plan in effect against the Commission. Miriam and Duncan discussed how they would rip off his employers of the $60 million stored at the Commission's leader's mansion. In the basement was a giant walk-in safe. Meanwhile, Barry was forming an alliance of his own. With help from his new family, three canines from his mother's past, and members from the Commission themselves, they came up with a brilliant plan. During confrontation from both sides, including Duncan's assistants, Barry and his team won. Duncan was arrested by the National Humane Bureau, along with other charges. Miriam went bonkers. The $60 million was split between Barry's family, and some went to agencies for homeless and helpless animals.