Maryann Caton is a tenacious environmental attorney who is glad that when she is craving solitude she can escape Manhattan for the only positive takeaway from her recent divorce--her country home in Roxbridge, Connecticut. But just when she thinks her life is finally resuming normalcy again, Maryann decides to drop her son, Jake, off at a school activity and visit The Guggenheim where fate intervenes and changes everything.

Rob MacKenzie is an introspective science educator who immediately captures Maryann's attention with his rather bizarre behavior inside the museum. After he confesses he is conducting legitimate research for an article he is writing for a children's magazine, the two continue their conversation over coffee, instigating an eventual romantic relationship. As Rob continues work on a new book of poems, Maryann delves into a South Carolina nuclear waste case. What neither knows is that very soon they will both be firmly entrenched in defending Roxbridge from becoming a nuclear waste warehouse. But if they succeed, what will be the cost?

MacKenzie's Farewell shares the tale of two environmental activists who must fight to prevent a low-level nuclear waste dump from moving into a Connecticut town.