As the world watched the biggest global epidemic in history evolve, many anticipated that Christians would embrace those who were affected just as Jesus during his time embraced those who were sick and dying. Mostly, the Christian church stood back and observed. Sometimes Christians responded with stigma and discrimination. Many who sought refuge in the churches–churches where they had served the sick and the poor–were turned away as they now sought refuge for themselves and their children. Individual authors address the critical issues related to the HIV epidemic, women, and the Christian church: how the HIV epidemic affected so many women and children; what the Old and New Testaments teach about our responsibility to the poor, the needy, the sick, the widow, and the orphan; and how difficult it should be for Christians to ignore these teachings. The HIV epidemic continues, and millions of women and children bear a disproportionate share of the pain and suffering without a refuge. Although HIV is a specific disease, it serves as a paradigm for all Christians to ask what other needs they may be ignoring.