Hospital and Haven tells the story of an Episcopal missionary couple who lived their entire married life, from 1910 to 1938, among the Gwich'in peoples of northern Alaska, devoting themselves to the peoples' physical, social, and spiritual well-being. The era was marked by great social disruption within Alaska Native communities and high disease and death rates, owing to the influx of non-Natives in the region, inadequate sanitation and hygiene, minimal law enforcement, and insufficient government funding for Alaska Native health care. Hospital and Haven reveals the sometimes contentious yet promising relationship between missionaries, Alaska Natives, other migrants, and Progressive Era medicine.

St. Stephen's Mission stood at the center of community life and formed a bulwark against the forces that threatened the Native peoples' lifeways and lives. Dr. Grafton (Happy or Hap) Burke directed the Hudson Stuck Memorial Hospital, the only hospital to serve Alaska Natives within a several-hundred-mile radius. Clara Burke focused on orphaned, needy, and convalescing children, raising hundreds in St. Stephen's Mission Home. The Gwich'in in turn embraced and engaged in the church and hospital work, making them community institutions. Bishop Peter Trimble Rowe came to recognize the hospital and orphanage work at Fort Yukon as the church's most important work in Alaska.