This is the 3rd Course that has been organized at the presti gious E. Majorana Centre. The choice of the theme is not a casual one. In fact after rehabilitation and prevention which were the topics discussed in the previous courses of 1979 and 1982, this Course deals with subjects more deeply connected with the mechanisms of cardiac function and the pathological aspects that under this point of view characterize many specific diseases. The rapid development in the application of technology to the problems of Cardiological diagnosis has made it possible to study ventricular function in the evaluation of patients with apparent or suspected heart disease. Knowing that we are facing one of the most complex subjects in modern cardiology we wish to arouse the interest of researchers anrl cardiologists by comparing different experiences with the aim of giving an overall survey of the problems. The program has been divided into 4 chapters: 1. Systolic and diastolic ventricular function. 2. Specific studies of ventricular function using invasive and non invasive techniques. 3. Diseases with altered ventricular function. 4. Pharmacological manipulation of ventricular function. Our aim is not only to stimulate useful discussions in the faculty but also among the participants. I hope that we can achieve this. I should like to take this opportunity of thanking the co directors of the Course Prof. Jan Kellermann and Prof. Robert v vi PREFACE Leachman who have played an important part in the scientific organization.