\“Talk, Talk, Sweet Charlotte\” presents a unique and often candid investigation of certain psychological, emotional, and social considerations typically associated with autism. It describes the relationship that was built over a two year period when the author worked as a one on one aide with Charlotte Tate, a junior high student who has autism. Charlotte was non-verbal and very aggressive toward principals, vice principals, teachers, aides, and other students. Her behaviors had prevented her from participating in a regular classroom environment. The author traces his work with Charlotte and highlights qualities relating to belief, courage, and caring in various forms. The transformation of Charlotte from \“one of the toughest kids to work with\” to a student who has a \“thirst for knowledge\” is an inspirational, amazing story.