The Neurology of Neuroblastoma: Neuroblastoma as a Neurobiological Disease

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Neuroblastoma is the single most common solid tumour of childhood. Although children with small primary neuroblastomas alone are almost always cured by surgery, 65 per cent of children with neuroblastoma already have large bulky tumours or metastatic disease by the time of initial diagnosis. For these children, the 5-year survival rate is only somewhere between 5 per cent and 20 per cent with therapies including surgery, radiat ion, chemotherapy, and bone marrow transplantation. Dr Schor outlines an approach to these tumours in order to make a difference for these children. There is much information to support the notion that neuroblastomas represent a developmental aberration of the nervous system, rather than a de novo abnormality in a previously normal cell. While the remote, paraneoplastic effects of neuroblastoma are often the purview of the child neurologist, the neoplasm itself has been viewed and approached therapeutically in much the same manner as all other solid tumours, as the purview of the paediatric oncologist. This work takes the view that approaching neuroblastoma rather as a disorder of nervous system development offers new therapeutic possibilities for this common tumour of childhood.