Nuclear Factor B: Regulation and Role in Disease

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The transcription factor NF-kB and the signalling pathways regulating its activity constitute a paradigm of membrane to nucleus communication. NF-kB is central to a number of cellular functions including cell proliferation, apoptosis, and cellular differentiation. This transcription factor also plays essential roles in innate and acquired immunity, and its deregulation leads to important human diseases such as inflammation and cancer. Therefore NF-kB, together with the signalling pathways leading to its activation, constitute an attractive therapeutic target. This book reviews and synthesizes our knowledge on this interesting transcription factor. It should be of interest to those entering or already actively working in the NF-kB field, as well as a reference for students, established researchers, or clinicians with wider interests in the fields of molecular cell biology and biomedicine.