This text describes the vast opportunity created by unifying science and integrating technology, and recommends transforming ideas for individuals and society. We stand at the threshold of a new renaissance in knowledge based on the structure and behaviour of matter from the nanoscale up to the most complex system yet discovered, the human brain. Unification of science based on unity in nature and its holistic investigation should lead to technological convergence and a more efficient societal structure for reaching human goals. In the early decades of the twenty-first century, concentrated effort can bring together nanotechnology, biotechnology, information technology, and new humane technologies based in cognitive science. With proper attention to ethical issues and societal needs, rapid advances in convergent technologies have the potential to enhance both human performance and productivity. Examples of payoffs include improving work efficiency and learning, enhancing individual sensory and cognitive capabilities, revolutionary changes in healthcare, improving both individual and group efficiency, highly effective communication techniques including brain to brain interaction, perfecting human-machine interfaces, enhancing human capabilities for defense purposes, reaching sustainable development using NBIC tools, and ameliorating the physical and cognitive decline that is common to the ageing mind.