At a time of extraordinary challenges confronting the world, this book analyses some of the profound changes occurring in the development of cities and regions. It discusses the uncertainties associated with the stalling of hyper-globalization and asks whether this creates opportunities for resurgent regional economies driven by local capabilities, resource efficiencies and domestic production. Theory and evidence on socio-economic and environmental transitions underway in many regions are brought together. Implications of the shifting balance of global power towards emerging economies in the East are explored, along with the consequences of urbanisation in the global South for politics and democracy. Dilemmas surrounding migration are also discussed, including whether incomers displace local workers and depress wages, or bring benefits in the form of know-how, new technology and investment. More integrative concepts of the region and theories of regional development are analysed, recognising the role of human capital, knowledge, innovation, finance, infrastructure and institutions. This was originally published as a special issue of Regional Studies.