Microbiological Organic Chemistry: Useful Oxidoreductive Steroid Biotransformations

This book discusses the past several decades’ advances in microbiological oxidoreductive steroid chemistry, giving a convenient reference and resource for synthetic-steroid chemists and microbiologists working in the area of steroid biotransformations. The author highlights the significant advances that have been made to a powerful technology for the construction of steroids. An introductory chapter reviews the significance of microbiological steroid chemistry, giving examples of how steroid-biotransformation steps have been integrated into drug-product syntheses. The next chapter is dedicated to advances in genetically modified microorganisms, bacteria and fungi, capable of steroid oxidation and reduction; followed by another detailing the use of microbiological steroid chemistry to synthesize and study steroid-drug metabolites. Lastly, the book details numerous examples of steroid biotransformations - cataloging site-specific microbiological steroid oxidations and reductions using either naturally occurring, or genetically modified microorganisms.