Antioch in Syria critically reassesses this ancient city from its Seleucid foundation into Late Antiquity. Although Antioch’s prominence is famous, Kristina M. Neumann newly exposes the gradations of imperial power and local agency mediated within its walls through a comprehensive study of the coins minted there and excavated throughout the Mediterranean and Middle East. Patterns revealed through digital mapping and Exploratory Data Analysis serve as a significant index of spatial politics and the policies of the different authorities making use of the city. Evaluating the coins against other historical material reveals that Antioch’s status was not fixed, nor the people passive pawns for external powers. Instead, as imperial governments capitalised upon Antioch’s location and amenities, the citizens developed in their own distinct identities and agency. Antioch of the Antiochians must therefore be elevated from traditional narratives and static characterisations, being studied and celebrated for the dynamic polis it was.