Against the backdrop of an explosion of interest in new techniques for data collection and theory testing, this volume provides a fresh programmatic statement about comparative-historical analysis. It examines the advances and distinctive contributions that CHA has made to theory generation and the explanation of large-scale outcomes that newer approaches often regard as empirically intractable. An introductory essay locates the sources of CHA’s enduring influence in core characteristics that distinguish this approach, such as its attention to process and its commitment to empirically grounded, deep case-based research. Subsequent chapters explore broad research programs inspired by CHA work, new analytic tools for studying temporal processes and institutional dynamics, and recent methodological tools for analyzing sequences and for combining CHA work with other approaches. This volume is essential reading for scholars seeking to learn about the sources of CHA’s enduring influence and its contemporary analytical and methodological techniques.