South Dakota Crusader takes an in-depth look at Francis Case's life and times up to the day before he officially becomes a U. S. congressman. It begins by describing his family background and early years as one of five children born in rural Iowa, where his Methodist-minister father served ten pastorates before accepting a new assignment in South Dakota's Black Hills.

Next, Francis's high school, college, Marine Corps service, teaching, and graduate school careers are discussed in detail. The story then turns to his newspaper endeavors in Rapid City, Hot Springs, and Custer; and his involvement as a civic leader and unabashed Black Hills promoter.

Finally, the book recounts his three attempts to be elected to Congress, and the Epilogue contains a summary of his congressional career. As the story unfolds, short updates about his close-knit family are provided.