Physical examination and clinical diagnosis is the next step after the core subjects of Anatomy, Physiology, Pathology and Differential Diagnosis. Acquiring effective and safe clinical skills is perhaps the most important stage in the clinician’s progression from theory to application. This unique ground-breaking presentation harnesses the use of technology to develop a visual tool that stimulates and enhances learning. Case History taking forms the first major component in the process of arriving at a diagnosis. Taking a concise and focused case history requires good listening, interpersonal and analytical skills. In most cases the clinician would have developed their differential diagnosis on case history alone. Subsequent clinical examination and further diagnostic procedures must be based on the identification of emerging themes that will eventually give rise to the most probable diagnosis(es). The process of focused case history inquiry and the development of differential diagnosis is demonstrated in a unique and innovative approach by analyzing the progress of real clinical encounters.