Atherosclerosis: Experimental Methods and Protocols

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This truly unique volume provides a broad spectrum of techniques and assays pertinent for experimental atherosclerosis research. Practical information regarding sample collection, choice of model system, experimental design, and data analysis techniques are provided in each chapter. In addition novel animal models are discussed including genetically engineered mice. Traditional and newer methods for identifying and separating classes and subclasses of lipoproteins are included along with assays for more recently identified plasma proteins implicated in atherogenesis, such as cholesteryl ester transfer protein, homocysteine, glycated lipoproteins, and apolipoprotein. Chapters describe the isolation and culture of cells and clycosaminoglycans from atherosclerotic plaques and further elaborate on in vivo techniques for the collection and analysis of experimental atherosclerotic lesions. Finally, a comprehensive presentation of gene therapies is given, and is accompanied by a highly practical technique that has been successfully implemented in pigs. The compilations in this manual will benefit those researchers in pursuit of understanding, diagnosing, treating, and ultimately preventing atherosclerosis.