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In their novel approach to Drug Discovery, Maxwell and Eckhardt explore their thesis that the discovery of new drugs - especially of innovative therapeutic agents - is an independent dynamic process that demands the full attention of researchers, rather than a spontaneous consequence of investigative research. Faced with a dearth of quantitative information on how and where innovative drugs were discovered, the authors have developed considerable quantitative data about this process in order to provide a deeper understanding of its true nature. Drug Discovery: A Casebook and Analysis offers a unique quantitative survey of research since World War II that led to the development of 32 innovative therapeutic agents. Factual and concise, each chapter presents a review of the original scientific contributions associated with the discovery of a specific drug. These chapters are followed by a computer analysis of important variables and finally by an interpretation. Drug categories discussed include: cardiovascular and renal (including renal transplantation) psychiatric neurological rheumatological anesthesiological pulmonary gastrointestinal. Everyone interested in the basic or clinical research leading to important drugs - and the institutional interplay inherent in the process - will find Drug Discovery: A Casebook and Analysis a comprehensive, invaluable reference compendium!
