Drug Design: Cutting Edge Approaches

Pharmaceutical research draws on increasingly complex techniques to solve the challenges of drug design. Bringing together a number of informatics techniques, this title looks at modelling and bioinformatic strategies; structural genomics and X-ray crystallography; virtual screening; lead optimisation; ADME profiling and vaccine design. A number of relevant case studies, focussing on techniques that have demonstrated their use, concentrate on G-protein coupled receptors as potential disease targets. The book should be useful to drug discovery scientists, including medicinal and combinatorial chemists, molecular modellers, bio- and cheminformaticians, pharmacologists, university and pharmaceutical company libraries.