Modern agribusiness is one of the main generators of employment and income worldwide and plays a vital role in improving the production, quality, and quantity of food, feed, fiber, and fuel ensuring our world has the safest and most nutritious, abundant, and sustainable food supply possible. The global agribusiness industry with its offerings such as insecticides, herbicides, and fungicides as well as biotechnology products contributes to growing public expectations for food security and agricultural sustainability while addressing the industry’s global challenges, such as population growth and rising caloric consumption, increasing environmental stresses across the globe, a changing regulatory landscape, development of resistance to existing active ingredients and traits by investing in effective R&D programs and inventing new solutions.The book provides an update on state of the art crop protection research and highlights the pivotal role of novel chemistries for modern crop protection. Recent research and new directions in the synthesis and chemistry of agrochemicals, as well as new research approaches, tools and directions in the crop protection field including nematicides, biologicals and natural products are described and details on the design, synthesis, biology and/or structure-activity relationships of a series of new chemical entities targeting fungicides, insecticides, herbicides and nematicides provided. Furthermore future directions for advancing research and regulation of agricultural chemistry and pest management science, promoting public health, and preserving environmental quality are covered as well.