This symposium series volume was developed in order to share papers presented at the 245th ACS National Meeting on the topic of pilot plants. The Industrial and Chemical Engineering, Applied Chemical Technology Subdivision hosted a one-day symposium for industry and academic researchers to present and share their work and best practices on operations and safety in pilot plant environments. Designing and building pilot plants can be a big challenge, and this volume outlines the proper operations needed to run a plant safely, in both academic and industrial environments. The book addresses issues like chemical separation, chemical reactions, waste generation, process controls, and spatial considerations, as well as safety precautions. It describes ways in which plant designers and contractors can consider ease of operation, maintenance, pinch-points, and sampling, among other aspects. In contrast to workers in large-scale facilities, pilot plant workers in both industry and academia are not only exposed to hazardous substances, they are exposed to such materials in a smaller setting and thus to potentially greater concentrations. This book brings together workers and researchers in pilot plant environments to present and share their best practices as regards operations and safety.