This work brings together a new generation of drug historians and new historical sources to uncover the history of the drug trade and its regulations. While the US and Mexican governments developed anti-drug discourses and policies, which criminalized both high-profile traffickers and small-time addicts, these authorities also employed the criminals and cash connected to the drug trade to pursue more pressing political concerns. The politics, socioeconomic relations, and criminal justice system of modern Mexico has been shaped by standing public and covert state policies as well as by the interaction of subnational trajectories of drug production and trafficking. The essays in this study explore this complicated narrative and provide insight into Mexico’s history and the wider contemporary global drug trade.