This second installment of a multivolume work on the Hemenway Southwestern Archaeological Expedition of 1886-1889 focuses on a report written by Cushing on the origins and early months of the expedition. Hidden in several archives for a century, the Itinerary is assembled and presented here for the first time to offer not only a vivid account of the first attempt at scientific excavations in the Southwest, but also an exciting tale of travel through the region and an intellectual adventure story that sheds important light on the human past in Arizona’s Salt River Valley.