Recent Advances in Clinical Trial Design and Analysis

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Clinical trials have two purposes - to treat the patients in the trial, and to obtain information which increases our understanding of the disease and, especially, how patients respond to treatment. Statistical design provides a means to achieve both these aims, while statistical data analysis provides methods for extracting useful information from the trial data. Recent advances in statistical computing have enabled statisticians to implement a broad array of methods which previously were either impractical or impossible. Biostatisticians are now able to provide much greater support to medical researchers working in both clinical and laboratory settings. As the collective tool-kit of techniques for analyzing data has grown, it has become increasingly difficult for biostatisticians to keep up with all the developments in our own field. This text aims to bring together biostatisticians’ research and explain some of the more recent developments in biostatistics to clinicians and scientists who work in clinical trials.