Protein Structural Biology in Biomedical Research, Part A

This text covers aspects of protein structural biology which have led to recognition of fundamental relationships between protein structure and function. The first two chapters, for example, are concerned with identification and design of specific ligand binding site. Chapter 1, Protein Crystallography in Medicine describes medically-relevant proteins for which crystal structures have provided targets for drug design. Chapter 2 introduces strategies used in design of proteins with specified binding capabilities, and chapter 3 explores the most useful depictions of protein structure. Other topics covered in the rest of the book include threading ; the mathematical basis for probabilistic methods and the application of molecular dynamics simulations to problems of molecular recognition.