Amyotrophic lateral sclerosis otherwise known as Lou Gehrig’s or motor neuron disease is one of several degenerative diseases of the aging nervous system. This text neatly synthesises the recent explosion of research into this particular condition to construct a detailed and comprehensive overview. From its epidemiology, molecular biology and pathophysiology right through to clinical assessment and care, Drs Eisen and Krieger bring their research expertise and extensive clinical experience to provide this practical and thought-provoking account.