Amyotrophic lateral sclerosis (ALS), otherwise known as Lou Gehrig’s or motor neuron disease, is one of several degenerative diseases of the ageing nervous system. Commonly affecting those in their mid-50s and beyond, it is a progressive illness resulting in death within a few years. This text neatly synthesizes the recent explosion of research into this particular condition to construct a detailed and comprehensive overview. From its epidemiology, molecular biology and pathophysiology right through to clinical assessment and care, Professor Eisen and Dr Krieger use their research expertise and extensive clinical experience to provide this practical and thought-provoking account.