This book serves as a supplement to The Pyrazines, Volume 41 of the Chemistry of Heterocyclic Compounds series. It covers the literature published between 1979 and 2000, and–together with Volume 41–provides a complete, up-to-date reference for heterocyclic chemists. It emphasizes practical approaches to pyrazine chemistry, offers a full appendix of all simple pyrazines up to 2000, and features detailed coverage of the following topics: * Systematic descriptions of all primary synthetic routes to pyrazines * Other preparative routes to alkylpyrazines and their reactions * Halogenopyrazines and their synthetic uses * Oxypyrazines and trivial names for pharmaceutical or agrochemical pyrazines * Thiopyrazines * Amino-, nitro-, and other similar pyrazines and their reactions * Pyrazinecarboxylic acids and their derivatives The supplement features extensive cross-references to the original volume and uses chemical nomenclature as per current IUPAC recommendations