Antibacterial Agents: Chemistry, Mode of Action, Mechanisms of Resistance and Clinical Applications

Rosaleen J. Anderson,Paul W. Groundwater,Adam Todd,Alan Worsley

Antibacterial Agents: Chemistry, Mode of Action, Mechanisms of Resistance and Clinical Applications
Format
Paperback
Publisher
John Wiley and Sons Ltd
Country
United States
Published
22 June 2012
Pages
288
ISBN
9780470972458

Antibacterial Agents: Chemistry, Mode of Action, Mechanisms of Resistance and Clinical Applications

Rosaleen J. Anderson,Paul W. Groundwater,Adam Todd,Alan Worsley

Antibacterial agents act against bacterial infection either by killing the bacterium or by arresting its growth. They do this by targeting bacterial DNA and its associated processes, attacking bacterial metabolic processes including protein synthesis, or interfering with bacterial cell wall synthesis and function. Antibacterial Agents is an essential guide to this important class of chemotherapeutic drugs. Compounds are organised according to their target, which helps the reader understand the mechanism of action of these drugs and how resistance can arise. The book uses an integrated lab-to-clinic approach which covers drug discovery, source or synthesis, mode of action, mechanisms of resistance, clinical aspects (including links to current guidelines, significant drug interactions, cautions and contraindications), prodrugs and future improvements. Agents covered include quinolones, rifamycins, sulphonamides, trimethoprim, chloramphenicol, macrolides, tetracyclines, b-lactams, D-cycloserine, vancomycin, and isoniazid. Antibacterial Agents will find a place on the bookshelves of students of pharmacy, pharmacology, pharmaceutical sciences, drug design/discovery, and medicinal chemistry, and as a bench reference for pharmacists and pharmaceutical researchers in academia and industry.

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