Label-free Technologies for Drug Discovery

Over the past two decades the benefits of label-free biosensor analysis have begun to make an impact in the market, and systems are beginning to be used as mainstream research tools in many drug discovery laboratories. Label-Free Technologies For Drug Discovery summarises the latest and emerging developments in label-free detection systems, their underlying technology principles and end-user case studies that reveal the power and limitations of label-free in all areas of drug discovery. Key focus areas include the use of label-free technologies in: * screening technologies * high-content technologies * hit finding and hit validation strategies * mode of action and ADME/T * access to difficult target classes * cell-based receptor/ligand interactions particularly orphan receptors * non-invasive cell proliferation and in vitro cytotoxicity testing * antibody and small molecule affinity and kinetic analysis Label-Free Technologies For Drug Discovery is an essential guide to this emerging class of tools for researchers in drug discovery and development, particularly high-throughput screening and compound profiling teams, medicinal chemists, structural biologists, assay developers, ADME/T specialists, and others interested in biomolecular interaction analysis.