Polypharmacology in Drug Discovery

Polypharmacology can be the two-faced Janus in drug discovery and pharmacology: an adverse, off-target safety risk in some cases or a necessity for effectively treating complex diseases like psychosis and cancer. This book overviews these facets of polypharmacology to help drug discovery researchers both address adverse polypharmacology and approach the discovery of polypharmacological drugs, with a third section of the book uses selected case studies to illustrate drug discovery opportunities. This resource fosters interdisciplinary drug discovery research by guiding researchers in neighboring areas to polypharmacology.