Protein and Peptide Mass Spectrometry in Drug Discovery

With chapters provided by international leading experts, this book covers the most recent advancements in this area. Focusing on the pharmaceutical industry, the book addresses both emerging mass spectrometry techniques, including imaging mass spectrometry, ion mobility, and microwave-assisted mass spectrometry, and recent applications, including pharmaceutical analysis throughout each stage of drug development. The book stresses practice and applications, providing real world examples from industry contributors. The book starts with an overview of protein mass spectrometry (MS) methodology, followed by a discussion of studies involving the characterization of proteins and special topics related to drug discovery. Remaining chapters address newer techniques for determining protein structure, interactions with peptides, proteins, and ligands, and protein folding and unfolding.