Stroke Part I: Basic and epidemiological aspects

9 11/16 X 7 7/16 in Section 1: Historical perspective: The history of stroke and cerebrov ascular disease.

Section 2: Basic science overview and pathology:
The ischemic cascade and mediators of ischemic injury. Animal model s of ischemic stroke. Cerebral blood flow and ischemic penumbra. Neuro pathology of ischemic brain injury. Reperfusion injury after stroke: n eurovascular proteases and the blood-brain barrier. Gene induction, pro tein synthesis and related issues. Effects of gender and sex steroids o n ischemic injury. Ischemic tolerance as an active and intrinsic neurop rotective mechanism. Vascular endothelium and the blood-brain barrier. A cerebrovascular perspective of atherosclerosis. Blood coagulation an d fibrinolysis: mechanisms of thrombosis. Anatomy of the circulation of the brain and spinal cord. Cerebral vascular dysregulation in the isch emic brain. Experimental models in intracerebral hemorrhage.

Sec tion 3: Clinical epidemiology: The worldwide burden of stroke: curren t status and future projections. Stroke among women, ethnic groups, you ng adults and children. Clinical genetic issues in stroke.
Costs an