We are now living through a period of knowledge capitalism in which, as Castells put it, ‘the action of knowledge upon knowledge is the main source of productivity.’ In the face of such transformation, the economic, social and institutional contours of contemporary capitalism are being reshaped. At the heart of this world are an emergent set of economies, regions, institutions and peoples central of the flows and translations of knowledge. This book provides an interdisciplinary review of the triad of knowledge, space, economy on entering the twenty-first century. Drawing on a variety of disciplinary backgrounds, the first part of the book comprises a set of statements by leading authors on the role of knowledge in capitalism. Thereafter, the remaining two parts of the book explore the landscape of knowledge capitalism through a series of analyses of knowledge in action within a range of economic, political and cultural contexts. Bringing together a set of authors from across the social sciences, this book provides both a major theoretical statement on understanding the economic world and an empirical exemplification of the power of knowledge in shaping the spaces and places of today’s society.