This report summarizes a joint workshop convened by the Institute of Medicine and National Research Council with Fundacao Maria Cecilia Souto Vidigal in November 2014 in Sao Paulo, Brazil. The workshop presentations and discussions highlighted efforts made to scale program investments across health, education, nutrition, and social protection that aim to improve children’s developmental potential. Speakers explored four topics around scaling up program investments: impact, scalability, sustainability, and governance. Participants shared their experiences scaling up programs and implementing early childhood services into a comprehensive national policy. Scaling Program Investments for Young Children Globally synthesizes up-to-date evidence on effective programs and interventions in Latin America and other regions, including an account of their strengths and challenges. This report highlights the presentations and discussions of the event.