There has been a substantial resurgence of interest in nuclear power in the United States over the past few years. One consequence has been a rapid growth in the research budget of DOE’s Office of Nuclear Energy (NE). In light of this growth, the Office of Management and Budget included within the FY2006 budget request a study by the National Academy of Sciences to review the NE research programs and recommend priorities among those programs. The programs to be evaluated were: Nuclear Power 2010 (NP 2010), Generation IV (GEN IV), the Nuclear Hydrogen Initiative (NHI), the Global Nuclear Energy Partnership (GNEP)/Advanced Fuel Cycle Initiative (AFCI), and the Idaho National Laboratory (INL) facilities. This book presents a description and analysis of each program along with specific findings and recommendations. It also provides an assessment of program priorities and oversight.