Developed in collaboration with the Nigerian Academy of Science, this report explores the ways in which science-based private enterprises can be created and encouraged in Nigeria and other developing countries to provide products and services that government is unable to supply in a timely and sustainable manner. Focusing on three critical challenges to health and development– safe water, electrical lighting, and malaria therapy–the report identifies a sample technology to address each of these challenges with potential for commercialization in Nigeria and Africa, and uses that sample technology to identify opportunities and barriers to creating the science-based enterprises in Nigeria.