The United States Department of Energy’s (DOE) facilities stewardship is extremely important to the department’s ability to achieve its mission of protecting national, energy, and economic security with advanced science and technology and ensuring environmental cleanup. Intelligent Sustainment and Renewal of Department of Energy Facilities and Infrastructure evaluates the steps the department is taking to improve its facilities and infrastructure management. This report develops best-practice techniques for DOE real property asset management and guidelines for deciding when to repair, renovate, or replace DOE buildings.