This historic book may have numerous typos and missing text. Purchasers can usually download a free scanned copy of the original book (without typos) from the publisher. Not indexed. Not illustrated. 1982-01-01 edition. Excerpt: …Symptoms of intoxication include accelerated respiration, vomiting, increased body temperature, tachycardia, neuromuscular weakness, and cardiac failure. Subchronic Exposure Several studies have reported on oral administration of pentachlorophenol for 90 d. Knudsen e_t al. (l974) administered pentachlorophenol in the diet to Wistar rats at 0, 25, 50, and 200 ppm (0, l.25, 2.5, and l0 mg/kg per day, respectively). At 200 ppm, growth rate was reduced in females and liver weight was increased in males. At 50 and 200 ppm, hemoglobin was increased at 6 wk, but decreased by ll wk. No adverse effects were observed at 25 ppm. Kimbrough and Linder (l975) gave male rats pure or technical pentachlorophenol at l,000 ppm. Pathologic changes in the liver were observed and were of a greater magnitude with the technical sample. Sprague-Dawley rats given technical pentachlorophenol at 3 mg/kg per day had increased liver and kidney weights (Johnson e_t _al., l973). When the sample was purified to reduce the amount of dioxins, no effects were seen at this dosage. Chronic Exposure and Carcinogenicity The potential carcinogenicity of pentachlorophenol was studied by Innes t al. (l969) and by Schwetz e_t al. (l978). Both studies failed to reveal any increased incidence of neoplasia. In the Schwetz e_t al. (l978) study, Sprague-Dawley rats were given a pentachlorophenol sample (having a lower content of nonphenolics than does technical pentachlorophenol) in the diet at 0, l, 3, l0, and 30 mg/kg of body weight per day; males were exposed for 22 mo, and females for 24 mo. No significant increase in tumors was observed at any dosage. No toxic effects were observed in male rats at l0 mg/kg per day or less or in females at 3 mg/kg per day or less. In the…
