Since its founding in 1970, the Institute of Medicine has become an internationally recognized source of independent advice and expertise on a broad spectrum of topics and issues related to the advancement of the health sciences and education and public health. Institute activities, reports, and policy statements have gained a wide audience both in the United States and throughout the world. In this first formal history of the Institute, Professor Edward D. Berkowitz describes many of the important individuals and events associated with the Institute’s creation, operation, development, and accomplishments since its founding, as well as the issues and challenges the Institute has confronted over the years that have helped shape it and to which it has contributed potential solutions and responses.