Advanced Technology for Human Support in Space was written in response to a request from NASA’s Office of Life and Microgravity Sciences and Applications (OLMSA) to evaluate its Advanced Human Support Technology Program. This report reviews the four major areas of the program: advanced life support (ALS), environmental monitoring and control (EMC), extravehicular activities (EVA), and space human factors (SHF). The focus of this program is on long-term technology development applicable to future human long-duration space missions, such as for a hypothetical new mission to the Moon or Mars.