This book examines methods for selecting topics and setting priorities for clinical practice guideline development and implementation. Clinical practice guidelines are systematically defined statements to assist practitioner and patient decisions about appropriate health care for specific clinical circumstances. In its assessment of processes for setting priorities, the committee considers the principles of consistency with the organization’s mission, implementation feasibility, efficiency, utility of the results to the organization, and openness and defensibility - a principle that is especially important to public agencies. The volume also examines the implications of health care restructuring for priority setting and topic selection, including the link between national and local approaches to guidelines development.