This volume provides research on oxygen transport to tissue. Ninety chapters cover varying aspects, including: oxygen carriers, oxygen transport in organs - brain, heart and lung, skeletal muscle, and abdominal muscles, as well as systemic oxygenation in normal and disease states, oxygen transport in tumours, theoretical models and integrative approaches to oxygen transport to tissue, and methods and instrumentation. Leading researchers in the field detail such topics as: reactions of cross-linked methemoglobins with hydrogen peroxide, cerebral redox states following haemoglobin substitution, fractal analysis of cerebral haemoglobin content fluctuations, oxygenation of haemoglobin in the human brain, regulation of cerebral oxygen delivery, apoprotein E genotypes and traumatic brain injury, mitochondrial hyperoxidation after global cerebral ischemia, spontaneous fluctuations in oxygen tension and vasomotion, metabolic and haemodynamic oscillations in the brain, anoxic preconditioning in hippocampal slices, tissue supply areas in myocardium, oscillations in cerebral hemodynamics for functional activation studies, and the effects of ketamine and phenobarbitol on cerebral tissue oxygen tension.