This interrogation of Origen’s legacy for the 21st Century returns to old questions built upon each other over eighteen centuries of Origen scholarship-problems of translation and transmission, positioning Origen in the histories of philosophy, theology, and orthodoxy, and defining his philological and exegetical programmes. The essays probe the more reliable sources for Origen’s thought by those who received his legacy and built on it. They focus on understanding how Origen’s legacy was adopted, transformed and transmitted looking at key figures from the fourth century through the Reformation. A section on modern contributions to the understanding of Origen embraces the foundational contributions of Huet, the twentieth century movement to rehabilitate Origen from his status as a heterodox teacher, and finally, the identification in 2012 of twenty-nine anonymous homilies on the Psalms in a codex in Munich as homilies of Origen. Equally important has been the investigation of Origen’s historical, cultural, and intellectual context. These studies track the processes of appropriation, assimilation and transformation in the formation and transmission of Origen’s legacy. Origen worked at interpreting Scripture throughout his life. There are essays addressing general issues of hermeneutics and his treatment of groups of books from the Biblical canon in commentaries and homilies. Key points of his theology are also addressed in essays that give attention to the fluid environment in which Origen developed his theology. These essays open important paths for students of Origen in the 21st century.