The Neuropathology of Schizophrenia: Progress and Interpretation

The neuropathology of schizophrenia is one of the most controversial areas of research in psychiatry; however, in the last twenty years, there have been significant advances in our understanding of the topic. This book provides a much needed, balanced, comprehensive and up-to-date overview of this rapidly moving field. It starts by describing the findings derived from new imaging techniques and histological studies, focusing specifically on the morphology, arrangement and connectivity of the neurons making up the cortical cytoarchitecture, a feature thought to be central to understanding the pathology. This is followed by critical appraisal of the various interpretations placed upon these findings, such as the neurodevelopmental hypothesis. Finally, there are chapters considering the conceptual and methodological problems affecting the subject. This is a timely and unique book on this classic and controversial issue, with contributions from many of the leading international experts in the field.