Computational and Experimental Design of Biopharmaceutical Formulations
Vladimir I. Razinkov (Department of Drug Product Development, Amgen Inc., Seattle, WA, USA),Arnold McAuley (Department of Drug Product Development, Amgen, Thousand Oaks, CA, USA),Pavan Ghattyvenkatakrishna (Department of Drug Product Development, Amgen, Thousand Oaks, CA, USA),Deirdre Piedmonte (Department of Drug Product Development, Amgen, Thousand Oaks, CA, USA)
Computational and Experimental Design of Biopharmaceutical Formulations
Vladimir I. Razinkov (Department of Drug Product Development, Amgen Inc., Seattle, WA, USA),Arnold McAuley (Department of Drug Product Development, Amgen, Thousand Oaks, CA, USA),Pavan Ghattyvenkatakrishna (Department of Drug Product Development, Amgen, Thousand Oaks, CA, USA),Deirdre Piedmonte (Department of Drug Product Development, Amgen, Thousand Oaks, CA, USA)
Computational and Experimental Design of Biopharmaceutical Formulations outlines available experimental and computational tools. It describes a rational approach to formulation design not limited by experimental design that extends to modern methods of computational modeling. These methods include the modeling of protein structure and dynamics, and of solution properties in the presence of proteins and excipients. The chapters in this book consider computational modeling of protein-solution interactions, the design of early-stage formulation studies, the design of late-stage formulation studies, automation, high-throughput and control, design of lyophilized formulations, and emerging technologies in the future formulation development.
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