Mouse Models of Developmental Genetic Disease

Like humans, mice naturally develop diseases that affect their immune, endocrine, nervous, cardiovascular, skeletal, and other physiological systems. As such mouse has become the premier mammalian model system for studying such diseases as cancer, atherosclerosis, hypertension, diabetes, osteoporosis, and glaucoma; moreover, certain diseases that occur in humans but not normally in mouse-CF, ALS, Huntingdon’s disease, for example-can be induced by manipulating the mouse genome and environment. This volume reviews current research findings and thought on mouse models for such human diseases as diabetes, cancer, Alzheimer’s, coronary disease, and hypertension, to name a few. * Provides busy clinical and basic science researchers a one-stop overview and synthesis of the latest research findings and contemporary thought in the area. * Allows researchers to compare and contrast disease models and also to learn about what models have been developed for large-scale distribution. * Allows researchers to evaluate basic differences in mouse and human biology and propose alternate pathways and possible gene interactions of the disease.