Ubiquitin and Protein Degradation, Part B

SECTION I. UBIQUITIN AND UBIQUITIN DERIVATIVES

Chapter 1. Chemical and genetic strategies for manipulating polyubiq uitin chain structure; Chapter 2. Controlled synthesis of polyubiquitin chains; Chapter 3. Derivitization of the C-terminus of ubiquitin and u biquitin-like proteins using
Intein chemistry: Methods & Uses; Chapter 4. Preparation, characterization, and use of tagged ubiqu itin; Chapter 5. Knocking out ubiquitin proteasome system function in vivo and in vitro with genetically-encodable tandem ubi quitin; Chapter 6. Production of anti-polyubiquitin antibodies and thei r use for characterization and isolation of polyubiquitinated proteins; Chapter 7. Application of Ubiquitin Immunohistochemistry to Diagnosis o f Disease; Chapter 8. Mechanism-based proteomics tools based on ubiquit in and ubiquitin-like proteins: crystallography, activity profiling and protease identification

SECTION II. UBIQUIT IN-BINDING DOMAINS

Chapter 9. Identification and characterization of modular domains that bind ubiquitin; Chapter 10