Regenerative Medicine and Stem Cell Biology

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This textbook covers the basic aspects of stem cell research and applications in regenerative medicine. Each chapter includes a didactic component and a practical section. The book offers readers insights into:

How to

identify the basic concepts of stem cell biology and the molecular

regulation of pluripotency and stem cell development. How to

produce induced pluripotent stem cells (iPSCs) and the basics of

transfection. The biology

of adult stem cells, with particular emphasis on mesenchymal stromal cells

and hematopoietic stem cells, and the basic mechanisms that regulate them.

How cancer stem cells arise and metastasize, and their properties. How to develop

the skills needed to isolate, differentiate and characterize adult stem The

clinical significance of stem cell research and the potential problems

that need to be overcome.
Evaluating

the use of stem cells for tissue engineering and therapies (the amniotic

membrane)
The

applications of bio-nanotechnology in stem cell research. How

epigenetic mechanisms, including various DNA modifications and histone

dynamics, are involved in regulating the potentiality and differentiation

of stem cells. The scientific methods, ethical considerations and implications of stem cell research.